Background: Improving the quality of life is a major goal in the provision of health. The study aimed to identify level of quality of life and associated factors with it among pregnant and mothers of under five children in the Kwango district of the Democratic Republic of the Congo. Methods: A total of 1,333 pregnant women and mother of under five children age. In the total of 719 pregnant women and mother of under five children in the Kenge area and 614 in the Boko area, were selected for the study in 2017. As primary outcome, EuroQol 5Dimension was measured with respect to mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each domain was subdivided into three categories 1) no problem, 2) some problem and 3) problem if of these questions answered that there was a problem, they were defined as problematic. Descriptive statistics, chi-square test and logistic regression analysis was performed to analyze whether general and medical service-related characteristics affect quality of life. Result: In total, 302 (22.7%) individuals reported to have at least one problem. Education, income level, perceived quality of hospital services, hospital services utilization and post-partum problem were significantly associated quality of life. Conclusion: Official Development Assistance (ODA) projects in the Democratic Republic of Congo are required not only for the maternal health projects but also policies to raise education and income in order to improve the quality of life related to women’s health.
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